2009•Central South PharmacyRequires access

Acute toxicity and genetic toxicity test of coixan

Xiao Zhi-yong

Abstract

Objective To evaluate the toxicological security of coixan.Methods Acute toxicity and genetic toxicity(Ames test,micronucleus test of bone marrow cells in mice and sperm abnormality test in mice)were tested.Results LD50(per os) was higher than 20 g·kg-1.Ames test,micronucleus test of bone marrow cells in mice and shape abnormality test in mice were negative and lacked toxicity.Conclusion Coixan is non-toxicn.

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Key concepts: Micronucleus test, Ames test, Toxicity, Bone marrow, Acute toxicity, Micronucleus, Medicine, Biology