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2004•Carcinogenesis,Teratogenesis and MutagenesisRequires access

Acute Toxicity and Genetic Toxicity Tests of DMDBS

Hui Tang

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Abstract

BACKGROUNDAIM: To study the acute toxicity and genetic toxicity of DMDBS. MATERIAL AND METHODS: Acute toxicity test of mice,Ames test,micronucleus test of bone marrow PCE cell in mice,sperm shape abnormality test of mice. RESULTS: DMDBS was a substance with no toxicity according to the acute toxicity.The results of genetic toxicity tests were all negative,including Ames test,micronucleus test and sperm shape abnorˉmality test. CONCLUSION: DMDBS was a substance with no toxicity and had no genetic toxicity in this test.

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BACKGROUNDAIM: To study the acute toxicity and genetic toxicity of DMDBS. MATERIAL AND METHODS: Acute toxicity test of mice,Ames test,micronucleus test of bone marrow PCE cell in mice,sperm shape abnormality test of mice. RESULTS: DMDBS was a substance with no toxicity according to the acute toxicity.The results of genetic toxicity tests were all negative,including Ames test,micronucleus test and sperm shape abnorˉmality test. CONCLUSION: DMDBS was a substance with no toxicity and had no genetic toxicity in this test.

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Available abstract

BACKGROUNDAIM: To study the acute toxicity and genetic toxicity of DMDBS. MATERIAL AND METHODS: Acute toxicity test of mice,Ames test,micronucleus test of bone marrow PCE cell in mice,sperm shape abnormality test of mice. RESULTS: DMDBS was a substance with no toxicity according to the acute toxicity.The results of genetic toxicity tests were all negative,including Ames test,micronucleus test and sperm shape abnorˉmality test. CONCLUSION: DMDBS was a substance with no toxicity and had no genetic toxicity in this test.

Key concepts: Toxicity, Ames test, Micronucleus test, Acute toxicity, Sperm, Biology, Bone marrow, Pharmacology

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