Expression and Correlation of PTEN and Survivn in Ovarian Epithelial Carcinoma

Objective: To investigate the expression and correlation of PTEN and survivin in ovarian epithelia carcinoma.Methods: The expression of PTEN and survivin in 38 cases of ovarian epithelial carcinoma,21 benign tumors and 20 normal ovarian tissue were determined by S-P immunohistochemical method.Results: The positive rate of PTEN in the ovarian carcer tissue was lower than in the normal and benign ocarian tumors(P0.05).Survivin expression trend was opposite to that of PTEN.In ovarian epithelia carcinoma,negative correlation between expression of PTEN and survivin was abserved(r=-0.527,P=0.001).No different expression of PTEN and survivin among histological types or ages was found(P0.05).The expression level of PTEN and survivin were associated with differentiation,clinic stage(P0.05).Conclusions: PTEN and survivin may play an important role in the initation,development and prognosis of ovarian epithelia carcinoma and the combination of PTEN and survivin expression may be helpful in predicting the malignant degree and prognosis of ovarian epithelia cancer.