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2007•Journal of Shandong Medical CollegeRequires access

THE EFFECTS OF PROSTAGLANDIN E_1 ON SERUM INTERCELLULAR ADHESION MOLECULE-1 AND COLLAGEN TYPE IV IN PATIENTS WITH DIABETIC NEPHROPATHY

Yun-ying Li

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Abstract

Objective To explore the effect of prostaglandin E1(PGE1) on serum intercellular adhesive molecule-1(SICAM-1) and collagen Type-IV(C-IV) in patients with diabetic nephropathy.Methods 136 cases of early diabetic nephropathy were treated with 10μg of PGE1 and 100ml of normal saline once a day for 14 days as well as the routine treatment.The Changes of SICAM-1 and C-IV were observed and compared with the contrast group.Results There existed significant difference in the levels of SICAM-1,C-IV and urinary ablumin excretion rate(UAER) between the two groups(P0.01,P0.05).Conclusion PGE1 can effectively reduce the levels of SICAM-1 and C-IV in patients with early diabetic nephropathy to improve and protect renal functions.

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What this paper is about

Objective To explore the effect of prostaglandin E1(PGE1) on serum intercellular adhesive molecule-1(SICAM-1) and collagen Type-IV(C-IV) in patients with diabetic nephropathy.Methods 136 cases of early diabetic nephropathy were treated with 10μg of PGE1 and 100ml of normal saline once a day for 14 days as well as the routine treatment.The Changes of SICAM-1 and C-IV were observed and compared with the contrast group.Results There existed significant difference in the levels of SICAM-1,C-IV and urinary ablumin excretion rate(UAER) between the two groups(P0.01,P0.05).Conclusion PGE1 can effectively reduce the levels of SICAM-1 and C-IV in patients with early diabetic nephropathy to improve and protect renal functions.

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Available abstract

Objective To explore the effect of prostaglandin E1(PGE1) on serum intercellular adhesive molecule-1(SICAM-1) and collagen Type-IV(C-IV) in patients with diabetic nephropathy.Methods 136 cases of early diabetic nephropathy were treated with 10μg of PGE1 and 100ml of normal saline once a day for 14 days as well as the routine treatment.The Changes of SICAM-1 and C-IV were observed and compared with the contrast group.Results There existed significant difference in the levels of SICAM-1,C-IV and urinary ablumin excretion rate(UAER) between the two groups(P0.01,P0.05).Conclusion PGE1 can effectively reduce the levels of SICAM-1 and C-IV in patients with early diabetic nephropathy to improve and protect renal functions.

Key concepts: Medicine, Diabetic nephropathy, Internal medicine, Nephropathy, Endocrinology, Prostaglandin E1, Adhesion, Excretion

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THE EFFECTS OF PROSTAGLANDIN E_1 ON SERUM INTERCELLULAR ADHESION MOLECULE-1 AND COLLAGEN TYPE IV IN PATIENTS WITH DIABETIC NEPHROPATHY — Research Paper | ScholarLens