Relationship of urine monocyte chemoattractant protein-1 and serum intercellular adhesion molecule-1 with inflammatory response in diabetic nephropathy of T2DM patients

Objective To study the correlation of monocyte chemoattractant protein-l(MCP-1) and serum intercellular adhesion molecule-1(sICAM-1) with inflammatory response in diabetic nephropathy of T2DM patients.Method 90 diabetes mellitus patients were divided into three subgroups(n=30, each):normo-albuminuria(NA),micro-albuminuria(MA) and clinical albuminuria(CA).The MCP-1, sICAM-1 and hsC-RP were determined by ELISA respectively,which were compared with 30 normal controls(NO.Results The levels of serum MCP-1 did not differ among groups of NC,NA,MA and CA(P0.05).The levels of urine MCP-1 and serum sICAM-1 were progressively higher in CA group than in MA(P0.05 or P0.01),in MA than in NA(P0.01),and in NA than in NC(P0.01) .The urine MCP-1 and serum sICAM-1 correlated positively with UAER(r=0.891,P0.01;r=0.583, P0.01)and with serum hsC-RP(r=0.723,P0.01;r=0.625,P0.01).Conclusion The urine MCP-1 and serum sICAM-1 are associated with kidney damage and inflammatory response,and might serve as clues to potential predictors for the development of diabetic nephropathy.