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2011•Journal of Taishan Medical CollegeRequires access

Effect of lipo-prostaglandin E1 on serum soluble intercellular adhesion molecule-1 and high sensitive-C reactive protein levels in patients with early diabetic nephropathy

Yun Gao

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Abstract

Objective: To investigate the effect of lipo-prostaglandin E1 on serum soluble intercellular adhesion molecule-1(sICAM-1) and high sensitive-C reactive protein(hs-CRP) levels in patients with early diabetic nephropathy(DN).Methods: A total of 64 patients with early DN were randomly divided into treatment group(n=32) and control group(n=32),which were both treated with dietary control and oral hypoglycemic drugs or insulin,meanwhile,the treatment group were treated with lipo-prostaglandin E1 10 μg·d-1 into the pot of static drops for 14 days.The levels of sICAM-1 and hs-CRP in each group were detected.Results: The levels of sICAM-1 and hs-CRP were decreased significantly in lipo-prostaglandin E1 treatment group after 14 days(P0.01).Conclusion: lipo-prostaglandin E1 may depress the expression of sICAM-1 and hs-CRP,which may be one of the mechanisms for delaying the progress of early DN.

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Objective: To investigate the effect of lipo-prostaglandin E1 on serum soluble intercellular adhesion molecule-1(sICAM-1) and high sensitive-C reactive protein(hs-CRP) levels in patients with early diabetic nephropathy(DN).Methods: A total of 64 patients with early DN were randomly divided into treatment group(n=32) and control group(n=32),which were both treated with dietary control and oral hypoglycemic drugs or insulin,meanwhile,the treatment group were treated with lipo-prostaglandin E1 10 μg·d-1 into the pot of static drops for 14 days.The levels of sICAM-1 and hs-CRP in each group were detected.Results: The levels of sICAM-1 and hs-CRP were decreased significantly in lipo-prostaglandin E1 treatment group after 14 days(P0.01).Conclusion: lipo-prostaglandin E1 may depress the expression of sICAM-1 and hs-CRP,which may be one of the mechanisms for delaying the progress of early DN.

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Available abstract

Objective: To investigate the effect of lipo-prostaglandin E1 on serum soluble intercellular adhesion molecule-1(sICAM-1) and high sensitive-C reactive protein(hs-CRP) levels in patients with early diabetic nephropathy(DN).Methods: A total of 64 patients with early DN were randomly divided into treatment group(n=32) and control group(n=32),which were both treated with dietary control and oral hypoglycemic drugs or insulin,meanwhile,the treatment group were treated with lipo-prostaglandin E1 10 μg·d-1 into the pot of static drops for 14 days.The levels of sICAM-1 and hs-CRP in each group were detected.Results: The levels of sICAM-1 and hs-CRP were decreased significantly in lipo-prostaglandin E1 treatment group after 14 days(P0.01).Conclusion: lipo-prostaglandin E1 may depress the expression of sICAM-1 and hs-CRP,which may be one of the mechanisms for delaying the progress of early DN.

Key concepts: Prostaglandin E1, Diabetic nephropathy, Prostaglandin, Intercellular Adhesion Molecule-1, Intracellular, Internal medicine, Endocrinology, Adhesion

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Effect of lipo-prostaglandin E1 on serum soluble intercellular adhesion molecule-1 and high sensitive-C reactive protein levels in patients with early diabetic nephropathy — Research Paper | ScholarLens