2007•Practical Preventive MedicineRequires access

Effects of Atorvastatin on Expression of ICAM-1 After Cerebral Ischemia/reperfusion Injury in Rats

Lei Huang

Abstract

Objective To investigate the impact of atorvastatin on the expression of ICAM-1 in the rat's brain tissue after ischemia/ reperfusion(I/R) injury. Methods Rats were subjected to cerebral I/ R injury through the occlusion of the middle cerebral artery.Neurological deficits were determined according to the Longa′s score.The expression of ICAM-1 was detected by immuno-histochemical technique.The effusion of PMNLs in brain tissue was evaluated by HE staining.Results The expression of ICAM-1 in the ischemic territory increased after cerebral ischemia(P0.01), and peaked at 24h after ischemia.Atorvastatin treatment decreased the expression of ICAM-1(P0.05),inhibited the effusion of PMNLs(P0.05),and improved the Longa′s score(P0.05).Conclusion Atorvastatin-calcium protects the brain tissue against ischemia reperfusion injury through inhibiting the expression of ICAM-1 after focal cerebral ischemia reperfusion in rats.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Ischemia, Medicine, Atorvastatin, Reperfusion injury, ICAM-1, Brain tissue, Middle cerebral artery, Anesthesia