2009•Lishizhen Medicine and Materia Medica ResearchRequires access

Effects of Naoxinkang-tablet on the Cerebral Ischemical Reperfusion Injury

Yan Meng

Abstract

Objective To study the protective effect of Naoxinkang-tablet on cerebral ischemia reperfusion injury in rats and its mechanism.Methods The model of incomplete cerebral ischemia were induced by occluding the middle cerebral artery occlusion(MCAO).The protein expression of ICAM-1 was immunohistochemical method at 24 h,48 h and 72 h after cerebral ischemia.Results Naoxinkang-tablet could obviously improve detected by symptoms of the neurological deficit in cerebral ischemia rats,inhibit the expression of ICAM-1.Conclusion Noxinkang-tablet has protective effect on cerebral ischemia reperfusion injury in time and dose dependent manners by inhibiting ICAM-1 expression and anti-inflammation.

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Key concepts: Medicine, Ischemia, Reperfusion injury, Middle cerebral artery, Neurological deficit, Occlusion, Immunohistochemistry, Anesthesia