Therapeutic effect of oat β-glucans on serum lipid levels of rats with experimental hyperlipemia

Objective:To investigate the therapeutic effect of oat β-glucans on serum lipid levels of rats with experimental hyperlipemia.Methods: Rats were fed on high fat forage for 3 weeks to establish hyperlipemia models,then the model rats were orally given oat β-glucans at doses of 133,266 and 533 mg/(kg·d) separately.At the same time,there were 3 control groups including chitosan ligosaccharide[200 mg/(kg·d)],normal,and high blood lipid(model rats fed with distilled water).Serum levels of total cholesterol(TC),high density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C) were assayed in rats of all groups and the results were compared.Results: β-glucans obviously decreased the levels of TC and LDL-C and increased HDL-C in rat hyperlipemia models.The reduction of serum lipid level in 4-week β-glucans treatment rats was more obvious than that in 3-week β-glucans treatment rats.Besides,β-glucans showed an obvious dosage dependent effect in reducing serum lipid level without adverse effect.Oat β-glucans had a better lipid-reducing effect than ligosaccharide did.Conclusion: Oat β-glucans can obviously decrease serum lipid in rats with hyperlipemia.