Regulation of Lipid-lowering Mixture on blood lipid of hyperlipemia rats

Objective: To study the effects of Lipid-lowering Mixture(LM) on blood lipid and low density lipoprotein( LDL) oxidative susceptibility in rats with hyperlipidemia, and to elucidate the possible mechanism. Methods: 60 male Wistar rats were randomly divided into normal group, model group, simvastatin and LM high, middle, low dose groups. Except the rats in normal group, the rats in the other groups were fed with a high fat diet to establish the hyperlipidemia rat model. At the same time giving the corresponding prophylactic medication according to the grouping. After the model established, the blood lipids and LDL susceptibility to oxidation, rat liver tissue malondialdehyde(MDA) and glutathione peroxidase(GSH-Px) and the mRNA expression of liver LDL receptor(LDL-R) in rats were tested. Results: Compared with the model group, after preventive medication, the blood lipid levels in all LM groups had been controled in varying degrees, Lag time and Tmax were significantly prolonged, MDA level in liver tissue was reduced, GSH-Px activity in the liver tissue was increased, and the relative expression levels in liver LDL-R mRNA increased significantly, the differences were statistically significant(P0.05, P0.01). Conclusion: LM had good adjusting effect on blood lipid metabolism and protect liver by getting rid of peroxidation injury in hyperlipidemic rats.