The expression and clinical significance of vascular endothelial growth factor in breast cancer

Objective To study the role of vascular endothelial growth factor (VEGF) in development and evaluating prognosis of breast cancer. Methods S P immunohistochemical method was used to detect VEGF expression in breast benign and malignant disease. Results VEGF expression positive rate in breast cancer (72.5%) was higher than that in breast benign disease (2/8), the difference was significant ( P 0.05). In 40 cases of breast cancer, the expression of VEGF in lymphatic metastasic group (19/21) was more than that in none lymphatic metastasic group(12/19), the difference was significant ( P 0.05). Conclusion VEGF play an important role in development and evaluating prognosis of breast cancer.