The antibiotic resistance analysis of 219 strains escherichia coli(E. Coli) and the detection of ESBLs-producing E. coli

Objective To investigate the antibiotic resistance of Escherichia coli(E.coli)and the detection of ESBLs-producing and AmpC-producing E.coli in the first affiliated hospital of chengdu medical college and provide the credible antimicrobial susceptibility test(ATB) results for clinical antibiotic use.Methods A total of 229 clinical isolates or E.coli were collected from different districts of the first affiliated hospital of chengdu medical college from January 2004 to December 2008.Bacteria were identified with API system.K-B methods were performed to detect the drug resistances profiles of these strains.ESBLs-producing and AmpC-producing E.coli were detected according to CLSI.Results E.coli was sensitive to imipenem,piperacillin tazobactam,cefepime,ceftazidime,and the antibiotic resistance was 5.02%,24.66%,21.46%,26.27%,respectively.E.coli was resistant to amoxicillin,bactrim,ampicillin,tenebrimycin,Ofloxacin and the antibiotic resistances were all above 70%.Conclusion The antibiotic reisistant of E.coli isolated from clinic was increased.Clinical antibiotic use should accord to the AST results.We must pay more attention to ESBLs-and AmpC-produging E.coli.