ANALYSIS OF THE DRUG RESISTANCE OF ESBLS OF ESCHERICHIA COLI N URINARY TRACT INFECTION

[Objective] To investigate the prevalence of strains producing extended spectrum β-lactamase(ESBLs)in Escherichia coli,and supply the laboratory evidence for antibiotic rational application in clinic.[Methods]VITEK32-automatic identification system was used to identify the bacterium.The drug susceptibility was tested with the K-B method and the ESBLs producing strains detected by disconfirmed test.[Results]141 strains of Escherichia coli were detected and the Positive rate of ESBLs-producing E.coli was 38.1%.E.coli was sensitive to cefoxitin,imipenem,cefoperazone/sulbactam,and the antibiotic resistances were less than 20%.E.coli was resistance to ampicillin,cefazolin,cefotaxime,ceftriaxone,ciprofloxacin,levofloxacin and the antibiotic resistances were all over 50%.The resistance of 14 kinds of commonly used antibiotic in E.coli producing ESBLs was higher than that in E.coli on-producing ESBLs.[Conclusion]The antibiotic resistance of E.coli isolated from clinic of urinary tract infection was increased.Clinical antibiotic use should accord to the AST results.We must pay more attention to ESBLs-producing E.coli.