Clinical distribution and drug resistance of 228 strains of Pseudomonas aeruginosa

Objective To investigate the clinical distribution and drug resistance of Pseudomonas aeruginosa(PAE) to provide references for rational usage of antibiotics in clinic.Methods The characteristics of clinical distribution and drug resistance of 228 strains of PAE,isolated from May.2010 to Dec.2011 in this hospital,were retrospectively analyzed.Results Among 228 PAE isolates,most were collected from Respiratory Department,ICU and Department of Cerebral Surgery,accounting for 36.9%,27.2% and 23.2%.165 strains were isolated from sputum,accounting for 72.4%.The drug resistance rates of PAE to cefoperazone/sulbactam,imipenem,meropenem and amikacin were 0.0%,8.9%,9.6% and 8.3% respectively,to ampicillin,cefazolin and cefotaxime were higher than 67.0% and to ceftazidime,cefepime and piperacillin/tazobactam were lower than 30.0%.Conclusion The drug resistance of PAE might be serious.It should be strengthened to reinforce the monitoring on drug resistance and to standardize the application of antibacterials.