Clinical distribution and drug resistance of Pseudomonas aeruginosa

OBJECTIVE To analyze the clinical distribution and drug resistance of Pseudomonas aeruginosa(PAE)from Jan 2009 to May 2010 so as to provide reference for the clinical reasonable medication.METHODS The identification of P.aeruginosa strains isolated from the hospital was carried out by using full-automatic microbial identification system of BioMerieux(France),the drug resistance to common antibiotics was analyzed,and statistical analysis was performed by the means of Whonet 5.4 software.RESULTS Among 187 P.aeruginosa isolates,most of them were collected from respiratory department and ICU,accounting for 39.04% and 20.86%,respectively;totally 152 isolates were isolated from sputum,accounting for 81.28%.The results of drug susceptibility test revealed that imipenem,piperacillin/tazobactam,meropenem,and amikacin kept high antibacterial activity against PAE,and the resistance rates were 9.2%,11.3%,16.2% and 13.0%,respectively;the resistance rates of PAE to ampicillin,ampicillin/sulbactam,cefotetan,nitrofurantoin,and cefazolin were higher than 95.00%;the resistance rates to gentamicin,aztreonam,ceftazidime,and cefepime were lower than 50.00%.CONCLUSION The isolated PAE strains are mainly from sputum specimens obtained from patients with respiratory tract infections,and the drug resistance is serious.It is necessary to strengthen the monitoring of drug resistance so as to guide the reasonable use of antibiotics and control nosocomial infections.