Drug Resistance Analysis of Pseudomonas Aeruginosa Infection in Our Hospital from 2007-2009

OBJECTIVE:To explore the drug resistance trend of Pseudomonas aeruginosa(PAE) and to provide reference for rational use of antibiotics and drug resistance control.METHODS:PAE infection of our hospital from 2007 to 2009 was analyzed retrospectively.Results of susceptibility test of 556 strains of PAE were analyzed statistically.RESULTS:Isolated PAE produced more serious drug resistance to commonly used antibiotics.The antibiotics with average drug resistance rate50.0% were ceftriaxone(68.31%),cefotaxime(66.80%),gentamicin(58.19%),tobramycin(57.47%),aztreonam(52.41%),cefepime oxime(50.29%).Antibiotics with high sensitivity were amikacin(80.64%),ceftazidime(75.34%),piperacillin/tazobactam(66.37%) and andimipenem(61.15%).Drug resistance rate of ceftriaxone was the highest and increased year by year.Drug resistance rate of imipenem,cefepime oxime,ceftazidime decreased gradually.The drug resistance rate of PAE to other drugs was relatively stable.CONCLUSION:Drug resistance of PAE is relatively stable.Clinical physicians should choose reasonable antibiotics according to results of drug sensitivity results to improve clinical efficacy and reduce the generation of tolerant bacterial strains.