Pharmacodynamic Study of Yishen Tongluo in Rats with Nephrotic Syndrome by C-BSA

Objective:To study the holistic effect of Yishen Tongluo on treating rats with nephrotic syndrome(NS).Methods:50 rat models made by cationic bovine serum albumin(C-BSA) were devided into five groups at random,including the pathological pattern group,the control group(Shenyan Siwei Pian,SYSW) and Yishen Tongluo(YSTL) group.Each experimental group consisted of 10 rats and the normal group contained 10 normal rats in the same batch.All rats were examined 24 hours later for urine protein quantity(24huPro),albumin(Alb),serum creatinine(Scr) and blood urea nitrogen(BUN).Their pathological forms were also observed and positive area ratio examined.Results:In YSTL group,the 24huPro,Scr and BUN decreased(P0.01),while Alb increased(P0.01).Also,in YSTL group,the pathological damage,positive area ratio decreased in kidney(P0.01).It was much better than either the pathological pattern group or SYSW one respectively(P0.05,P0.01).Conclusion:YSTL had obvious effects on rats with NS.It could improve the relative proteins and the functions of kidney,and reduce the pathological damages.