Alteration of IL-6 and cell immune in patients with cerebral glioma

Objective:To determine the presence of Interleukin-6 (IL-6) and the alteration of erythrocyte immune and T cell subgroup in the blood of outer circulation in patients with cerebral glioma. To explore the relationship between them and the clinical significance. Methods:Enzyme linked immunosorbent assay (ELISA) was used to determine the content of IL-6.The immunoadsorption was employed to examine the erythrocyte immune activity and its function of regulation. Streptavidin-Peroxidase (S-P) was used to determine the cell number of CD3(cluster of differentiation 3),CD4,CD8.Results:The content of IL-6 in the group with cerebral glioma is significantly lower than that in the control group (P0.05). Red blood cell C3b receptor (RBC.C3bR) and RBC immune adherence enhance factor (RFER) dropped greatly (P0.001), while Red blood cell immune complex rosstte RBC.ICR) and RBC immune adherence inhibitor factor (RFIR) increased greatly. The cell number of CD3,CD4 dropped (P0.01) and there was no evident change of CD8 (P0.05).Conclusion:The decrease of immune function was observed in the patients with cerebral glioma. The determination of the content of IL-6 ,erythrocyte immunization and the activity of T subgroup has important clinical guiding significance in the occurrence,development ,treatment, outcome and prognosis of the cerebral glioma.