Alteration and significance of IL-2,sIL-2R and cell immune in patients with cerebral glioma

Objective To study the alteration in expressions of interleukin-2(IL-2) and soluble interleukin 2 receptor(sIL-2R),erythrocyte immune and T cell subgroup in the peripheral blood in the patients with cerebral glioma,and explore the relationships between them.Methods In 55 patients with cerebral gliomas and 55 healthy blood donors,ELISA was used to determine the contents of IL-2 and sIL-2R,immunoadsorption employed to examine the erythrocyte immune activity and its regulatory function,and streptavidin-peroxidase immunohistochemical method used to determine cell numbers of CD3(cluster of differentiation 3),CD4,and CD8.Results The content of IL-2 in cerebral glioma group was significantly lower than that in the control group(P0.01) and that of sIL-2R increased significantly(P0.01).RBC-C3b receptor and RBC immune adherence-enhancing factor dropped markedly(P0.01),while RBC immune complex rosette and RBC immune regulation-inhibiting factor were greatly increased(P0.01).The cell number of CD3,CD4 decreased(P0.001),and there was no evident change of CD8(P0.05).Conclusions Suppression of immune function was observed in the patients with cerebral glioma.The determination of IL-2 and sIL-2R levels,immune function of WBC and activity of T subgroup has important significance in study of immune system in patients with cerebral glioma.