Changes and Its Clinical Significance of Erythrocyte Immune Function and T Lymphocyte Subsets in Patients with Acute Cerebral Vascular Disorder

Objective The changes and its clinical significance of erythrocyte immune function and T lymphocyte subsets were studied in patients with acute cerebral vascular disorders(ACVD).Methods Erythrocyte immune function(including RBC C3bRR and RBC ICR) and T lymphocyte subsets(including CD3 +、CD4 +、CD8 +、CD4 +/CD8 +) were measured in 79 ACVD patients by the immune adherence rosette and the direct immunofluroscent staining technique.Results RBC C3bRR、CD3 +、CD4 + and CD4 +/CD8 + decreased markedly while RBC ICR increased relatively during acute period of CVD as compared with normal group. The effects on cell immune function vary with different cerebral focal lesions as in the following order of degree : basic ganglia brain stemfrontal lobe parietal lobe temporal lobe cerebellum occipital lobel.Cell immune function declined markedly while hemorrhage volume or infarct area were more severe.There was a positive relationship between RBC C3bRR and CD4 +/CD8 +.Conclusions Severe erythrocyte and T lymphocyte immune functional decline and disbalance were observed in ACVD patients. Character of brain lesions (infarct or hemorrhage) was not the decisive factor while site of cerebral lesion and severity did.