β-Fibrinogen-455G/A Gene Polymorphism in Essential Hypertension

Objective To explore the β-fibrinogen (Fg) gene polymorphism in Chinese Han population and the association of the polymorphisms with essential hypertension(EH). Methods The β-Fg-455G/A gene polymorphism was identified by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) in 149 patients with EH and 148 healthy controls matched by age and sex. Turbidimetric assays were performed to measure the plasma fibrinogen levels. Results The distribution of β-Fg-455G/A gene polymorphism was in accordance with the Hardy-Weinberg equilibrium( P 0.05). The A-allele is associated with elevated plasma fibrinogen levels in both hypertensives and controls. The A-allelic frequency in EH group and the control group were 0.171 and 0.152. No significant difference was found between them( P 0.05). Conclusion There is no association between the β-Fg-455G/A gene polymorphism and essential hypertension.