A80C polymorphism of tumor necrosis factor-β gene and essential hypertension

Objective To investigate the association between A80C polymorphism in exon 1 of tumor necrosis factor-β (TNF-β) gene and essential hypertension (EH) in Chinese Han population. Methods The A80C polymorphism in exon 1 of TNF-β gene was analyzed by matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS) in 122 patients with EH and 202 healthy controls. Results The genotype distribution and alleles frequencies of A80C polymorphism were not significantly different between the two groups (P0.05). However,further subgroup analysis showed that the genotype distribution of A80C polymorphism was significantly different between EH group and control group in females (P0.05). The odds ratio of EH in females carrying CC genotype compared with A allele carriers was 2.27 (95% CI:1.111-4.656). Allele frequency was not significantly different between the two subgroups (P0.05). Serum total cholesterol and low-density lipoprotein cholesterol(LDL-C) levels in female EH patients carrying CC genotype were significantly higher (P0.01). Conclusions A80C polymorphism in exon 1 of TNF-β gene might be associated with the development of hypertension in Chinese female Han population,especially in those carrying CC genotype.