Experimental study of Zinc affect Lipid peroxidation of arsenic on liver and kidney in mice

Objective: To investigate the effect of arsenic on lipid peroxidation in mice liver and observe the intervention effect of zinc supplement.Methods: Sixty health Kunming mice were divided into five groups(negative control group,the positive control group,three zinc intervention group),a sub-chronic toxicity test methods,oral gavage for six weeks until the end of the experiment were killed.Lipid peroxidation malondialdehyde(MDA) content,superoxide dismutase(SOD),activity of glutathione peroxidase(GSH-Px) in mice liver and kidney were measured.At the same time observed after the intervention of zinc in mice with arsenic levels of anti-oxidation.Results: The results showed that with the increases of exposure levels of arsenic,the contents of MDA was significantly increased and the activities of SOD and GSH-Px were significantly decreased.Zinc could decrease the contents of MDA and increase the activities of SOD and GSH-Px significantly.Conclusion: The arsenic could induce lipid peroxidation in mice and zinc could inhibit the lipid peroxidation result in exposed to arsenic.