An intervention study of zinc and selenium on arsenic induced lipid peroxidation in mice

Objective:To investigate the effect of arsenic on lipid peroxidation in mice liver and observe the intervention effect of zinc and selenium supplement.Methods:Subchronic toxicity experiment was applied.Then the mice organism and serum contents of lipid peroxides degradation product malondialdehyde(MDA),the contents of glutathione S-transferase(GST),the total superoxide dismutase(SOD) activities and glutathione peroxidase(GSH-Px) activities in serum and liver were determined individually.Meanwhile,study the influence of anti-oxidation activity in mice exposured to arsenic with zinc and selenium supplement.Results:The results showed that with the increases of exposure levels of arsenic,the contents of MDA and GST significantly increased and the activities of SOD and GSH-Px significantly decreased and showed a dose-effect manner.Zinc and selenium could decrease the contents of MDA and GST and increase the activities of SOD and GSH-Px significantly.Conclusion:The arsenic could induce lipid peroxidation in mice and zinc and selenium could inhibit the lipid peroxidation result in exposed to arsenic.