Experimental study on intervene action of zinc, selenium on arsenic induced lipid peroxidation in mice

To investigate the effect of arsenic on lipid peroxidation in mice liver and observe the intervention effect of zinc and selenium supplement [Methods] Subchronic toxicity experiment is applied. Then the mice organism and serum contents of lipid peroxides degradation product malondialdehyde (MDA), the contents of glutathione S-transferase (GST), the total superoxide dismutase (SOD) activities and glutathione peroxidase (GSH-Px) activities in serum and liver are determined individually. Meanwhile, study the influence of anti-oxidation activity in mice exposures to arsenic with zinc and selenium supplement. [Results] The results show that with the increases of exposure levels of arsenic, the contents of MDA and GST are significantly increased and the activities of SOD and GSH-Px are significantly decreased and show a dose-effect manner. Zinc and selenium can decrease the contents of MDA and GST and increase the activities of SOD and GSH-Px significantly. [Conclusion] Arsenic could induce lipid peroxidation in mice and zinc and selenium can inhibit the lipid peroxidation after arsenic exposure.