2004•Xinjiang Yike Daxue xuebaoRequires access
Experimental Study on Lipid Peroxidation of Arsenic on Liver and Kidneys in Mice
Yan Wang
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Abstract
Objective: To investigate the effect of arsenic on lipid peroxidation in mice liver and kidneys and observe the intervention effect of vitamin E(VitE) supplement. Methods: Subchronic toxicity experiment was applied. Then the mice organism content of lipid peroxides degradation product malondialdehyde (MDA), the total superoxide dismutase (SOD) activity and glutathione peroxidase (GSH Px) activity in liver and kidneys were determined individually. Meanwhile, study the influence of anti oxidation activity in mice exposured to arsenic with VitE supplement. Results: The results showed that with the increases of exposure levers of arsenic, the content of MDA was significantly increased and the activity of SOD and GSH Px were significantly decreased and showed a dose effect manner. VitE could decrease the content of MDA and increase the activity of SOD and GSH Px significantly. Conclusion: The arsenic could induce lipid peroxidation in mice liver and kidneys and VitE could inhibit the lipid peroxidation result in exposed to As\-2O\-3.