Quantitative tissue velocity imaging in evaluation of left ventricular function in patients with hyperthyroidism

Objective: To evaluate the left ventricular function in patients with hyperthyroidism by quantitative tissue velocity imaging(QTVI).Methods: According to the clinical diagnostic standard,53 patients with hyperthyroidism were divided into hyperthyrod heart disease group and the non-hyperthyrod heart disease group,and 40 normal subjects served as the control.Conventional two-dimensional echocardiography was performed on all subjects to obtain the left atrial end systolic diameter(LAd),the left ventricular end diastolic diameter(LVEDd),left ventricular posterior wall diameter(LVPWd) and left ventricular ejection fraction(LVEF).The transmitral flow was obtained by pulsed-wave Doppler,and the peak velocity of the early(E) and later(A) diastolic waves were measured,then the ratio of E/A was calculated.The TDI pictures of apical views(2,3,and 4 chambers) for three stable and consecutive cardiac cycles were stored and transferred to Echo PAC(GE Hearth care) for analysis.Peak systolic velocity of left ventricular mitral annulus(Vs),early diastolic peak velocity(Ve) and late diastolic peak velocity(Va) and the ratio(Ve/Va) were measured.Results: Compared with the normal group,the LAd,LVPWd and LVEF in the non-hyperthyrod heart disease group were statistically different(P0.05);the LAd,LVEDd,E,A and E/A in the hyperthyrod heart disease group were statistically different(P0.05);Vs and Va in in the non-hyperthyrod heart disease group were significantly increased while Vs/Va was significantly decreased(P0.01).In the hyperthyrod heart disease group,Vs,Va and Vs/Va were all decreased(P0.01).Conclusions: QTVI is an effective tool to evaluate the heart damage caused by hyperthyroidism.Ve/Va is a sensitive parameter in evaluating the early cardiac diastolic dysfunction and Vs is sensitive to detect cardiac systolic dysfunction due to hyperthyroidis.