Clinical analysis of 10-15 weeks of pregnancy termination with Mifepristone and Misoprostol

Objective To discuss the clinical effects of different medication methods with Mifepristone and Misoprostol in women of pregnancy termination for 10-15 weeks.Methods 300 patients were distributed into study group with 150 cases and control group with 150 cases.Two groups were both treated by Mifepristone and Misoprostol,but with different medication methods.Control group took Mifepristone at 7∶00 daily morning and evening with 3 days,then took Misoprostol at 7∶00 in the 4th morning.Study group took Mifepristone at 7∶00 in the 1st evening and took Misoprostol at 7∶00 in the 2nd morning,and was put Misoprostol into patients' vagina.The gestational sac time,vaginal bleeding and side effects were observed.Results The complete abortion rate of study group were significantly higher than control group,incomplete abortion rate and abortion failed rate of study group were significantly lower than control group(P 0.05).The average discharge time of gestational sac of study group was(10.32±3.61) d and control group was(15.81±5.63) d,the two groups had significant difference(P 0.05).The rate of vaginal bleeding approximate menstrual flow in study group was significantly higher than control group(P 0.05).The incidence rate of fever,limb numbness,diarrhea,nausea,vomiting in study group were significantly lower than control group(P 0.05).Conclusion The method of low times,larger doses combined with vaginal delivery of Mifepristone and Misoprostol is more effective and safe in 10-15 weeks' pregnancy termination,and suitable for clinical application.