ScholarLens Back to search
2010•Liaoning Yixueyuan xuebaoRequires access

Effect of Resveratrol on Focal Cerebral Ischemic-reperfusion Injury in Rats

Dongyu Wang

Open publisher page 0 citations

Abstract

Objective To Investigate the effect of resveratrol on focal cerebral ischemic-reperfusion injury in rats.Methods We divided 126 SD mice randomly into 3 groups: shame operation group(SO),ischemia/ reperfusion group(I/R),Res group.Each group is divided into 3 subgroups: reperfusion 6 h,24 h and 48 h after ischemic for 2 h.The contents of inducible nitricoxide synthase(iNOS),malondialdehyde(MDA) and activities of superoxide disnutase(SOD) in brain tissue were measured.Results Resveratrol could significantly improve the activities of SOD in brain tissue;lower the content of MDA,iNOS.Conclusions Resveratrol has an obvious protective effect on focal cerebral ischemia-reperfusion injury in rats,and its treatment mechanism may come from effectively scavenging free radicals and improving the anti-oxidative ability of the brain tissue.

About this research paper

What this paper is about

Objective To Investigate the effect of resveratrol on focal cerebral ischemic-reperfusion injury in rats.Methods We divided 126 SD mice randomly into 3 groups: shame operation group(SO),ischemia/ reperfusion group(I/R),Res group.Each group is divided into 3 subgroups: reperfusion 6 h,24 h and 48 h after ischemic for 2 h.The contents of inducible nitricoxide synthase(iNOS),malondialdehyde(MDA) and activities of superoxide disnutase(SOD) in brain tissue were measured.Results Resveratrol could significantly improve the activities of SOD in brain tissue;lower the content of MDA,iNOS.Conclusions Resveratrol has an obvious protective effect on focal cerebral ischemia-reperfusion injury in rats,and its treatment mechanism may come from effectively scavenging free radicals and improving the anti-oxidative ability of the brain tissue.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To Investigate the effect of resveratrol on focal cerebral ischemic-reperfusion injury in rats.Methods We divided 126 SD mice randomly into 3 groups: shame operation group(SO),ischemia/ reperfusion group(I/R),Res group.Each group is divided into 3 subgroups: reperfusion 6 h,24 h and 48 h after ischemic for 2 h.The contents of inducible nitricoxide synthase(iNOS),malondialdehyde(MDA) and activities of superoxide disnutase(SOD) in brain tissue were measured.Results Resveratrol could significantly improve the activities of SOD in brain tissue;lower the content of MDA,iNOS.Conclusions Resveratrol has an obvious protective effect on focal cerebral ischemia-reperfusion injury in rats,and its treatment mechanism may come from effectively scavenging free radicals and improving the anti-oxidative ability of the brain tissue.

Key concepts: Resveratrol, Malondialdehyde, Ischemia, Brain tissue, Reperfusion injury, Superoxide dismutase, Pharmacology, Neuroprotection

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effect of Resveratrol on Focal Cerebral Ischemic-reperfusion Injury in Rats — Research Paper | ScholarLens