2009•Chengde Yixueyuan xuebaoRequires access

CHANGES OF SOD AND MDA IN BRAIN OF FOCAL CEREBRAL ISCHEMIA-REPERFUSION MODEL RATS

Chen Meng

Abstract

Objective:To observe the changes of superoxide dismutase(SOD)and malondialdehyde(MDA) in brain of focal cerebral ischemia-reperfusion model rats.Methods:The focal cerebral ischemia-reperfusion model rats were established by suture embolic method.TCC was used to display infraction scope;the SOD activity and MDA content in reperfusion injury brain were measured.Results:Compared with control group,in focal cerebral ischemia-reperfusion rats model brain,the SOD activity decreased and MDA content increased obviously(P0.01).Conclusions:Focal cerebral ischemia-reperfusion can obviously decrease SOD activity and increase MDA content in reperfusion injury brain.

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Key concepts: Malondialdehyde, Ischemia, Superoxide dismutase, Reperfusion injury, Medicine, Anesthesia, Brain tissue, Internal medicine