Effect of Resveratrol on Focal Cerebral Ischemia Reperfusion Injury Via Ameliorating Oxidative Stress in Rats

Objective To investigate the effect of resveratrol(Res) on focal cerebral ischemia reperfusion injury via ameliorating oxidative stress in rats.Methods SD rats were divided into sham operation(S),ischemia / reperfusion [I / R,i.e.rat model of cerebral artery occlusion(MCAO) copied by intraluminal thread] as well as Res at low(I / R + R1,15 mg / kg) and high(I / R + R2,30 mg / kg) dosage groups,of which the lesions of neurological function were scored 2 h after ischemia and 24 h after reperfusion separately,while determined for malondialdehyde(MDA) content and superoxide dismutase(SDO) activity in serum and brain tissue by chemical colorimetry,for infarct volume by TTC method,for moisture content in brain tissue by dry and wet weight method,and for pathological change of brain tissue by HE staining.Results Res improved the neurological deficit caused by cerebral ischemia reperfusion injury(P 0.01),decreased the MDA content(P 0.01) and increased the SDS activity in serum and brain tissue(P 0.01),while decreased the infarct volume(P 0.01) and the moisture content in brain tissue(P 0.01),and improved the pathological changes of brain tissue,each in a dose-dependent pattern.Conclusion Res showed good protective effect on the cerebral ischemia reperfusion injury via ameliorating oxidative stress by a potential mechanism which might be associated with the clearance of free radicals and the relief of oxidative damage.