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The Treatment Effect of Resveratrol on Focal Cerebral Ischemic Rat

Lize Xiong

Open publisher page 1 citations

Abstract

Objective: To investigate the effect of resveratrol on rats with focal cerebral ischemia reperfusion injury and the possible mechanism.Methods: The SD rats were randomly divided into two groups: control group(n=16) and resveratrol group(n=16).The rats in the control group were injected with 0.5 ml saline intraperitoneal,while rats in the resveratrol groups were given 20 mg/kg resveratrol after perfusion.The neurobehavioral scores,infarct volumes,the change of MPO,SOD and MDA were detected 22 hours after reperfu-sion.Results: Resveratrol treatment could improve neurobehavioral score and reduce infarct volumes after 22 h of reperfusion(P 0.05).Meanwhile,it could increase brain soluble SOD activity,and decrease the MDA and OMP content.Conclusion: Resveratrol play a thera-peutic role on rats with focal cerebral ischemia reperfusion injury by reducing leukocyte infiltration and increasing free radical scavenging rate.

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What this paper is about

Objective: To investigate the effect of resveratrol on rats with focal cerebral ischemia reperfusion injury and the possible mechanism.Methods: The SD rats were randomly divided into two groups: control group(n=16) and resveratrol group(n=16).The rats in the control group were injected with 0.5 ml saline intraperitoneal,while rats in the resveratrol groups were given 20 mg/kg resveratrol after perfusion.The neurobehavioral scores,infarct volumes,the change of MPO,SOD and MDA were detected 22 hours after reperfu-sion.Results: Resveratrol treatment could improve neurobehavioral score and reduce infarct volumes after 22 h of reperfusion(P 0.05).Meanwhile,it could increase brain soluble SOD activity,and decrease the MDA and OMP content.Conclusion: Resveratrol play a thera-peutic role on rats with focal cerebral ischemia reperfusion injury by reducing leukocyte infiltration and increasing free radical scavenging rate.

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Available abstract

Objective: To investigate the effect of resveratrol on rats with focal cerebral ischemia reperfusion injury and the possible mechanism.Methods: The SD rats were randomly divided into two groups: control group(n=16) and resveratrol group(n=16).The rats in the control group were injected with 0.5 ml saline intraperitoneal,while rats in the resveratrol groups were given 20 mg/kg resveratrol after perfusion.The neurobehavioral scores,infarct volumes,the change of MPO,SOD and MDA were detected 22 hours after reperfu-sion.Results: Resveratrol treatment could improve neurobehavioral score and reduce infarct volumes after 22 h of reperfusion(P 0.05).Meanwhile,it could increase brain soluble SOD activity,and decrease the MDA and OMP content.Conclusion: Resveratrol play a thera-peutic role on rats with focal cerebral ischemia reperfusion injury by reducing leukocyte infiltration and increasing free radical scavenging rate.

Key concepts: Resveratrol, Ischemia, Saline, Infiltration (HVAC), Intraperitoneal injection, Reperfusion injury, Medicine, Perfusion

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