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2009•Journal of Heze Medical CollegeRequires access

The Clinical Significance of Cyclooxygenase-2(COX-2) and Vascular Endothelial Growth Factor(VEGF) in Cervical Cancer

Lin Zhao

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Abstract

Objective To investigate the expression of cyclooxygenase-2(COX-2) and vascular endothelial growth factor(VEGF)and their relationship with the clinical pathological characteristics of cervical cancer.Methods The expression of COX-2 and VEGF were examined immunohistochemically in 56 cases of cervical cancer and 15 of normal cervix.Results The positive rate of COX-2 and VEGF were significantly different between the cervical carcinoma and normal cervix.The expression of COX-2 in cervical cancer was significantly related to the histological subtypes,the metastasis of lymph node and the differentiation(P0.05);while the expression of VEGF was closely related to clinical stage,the metastasis of lymph node(P0.05).The expression of VEGF was closely associated with COX-2(P0.01).Conclusion The expression of COX-2 and VEGF are related to the oncogenesis and development of cervical cancer and they may play important roles in the invasion and metastasis of cervical cancer.

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What this paper is about

Objective To investigate the expression of cyclooxygenase-2(COX-2) and vascular endothelial growth factor(VEGF)and their relationship with the clinical pathological characteristics of cervical cancer.Methods The expression of COX-2 and VEGF were examined immunohistochemically in 56 cases of cervical cancer and 15 of normal cervix.Results The positive rate of COX-2 and VEGF were significantly different between the cervical carcinoma and normal cervix.The expression of COX-2 in cervical cancer was significantly related to the histological subtypes,the metastasis of lymph node and the differentiation(P0.05);while the expression of VEGF was closely related to clinical stage,the metastasis of lymph node(P0.05).The expression of VEGF was closely associated with COX-2(P0.01).Conclusion The expression of COX-2 and VEGF are related to the oncogenesis and development of cervical cancer and they may play important roles in the invasion and metastasis of cervical cancer.

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Available abstract

Objective To investigate the expression of cyclooxygenase-2(COX-2) and vascular endothelial growth factor(VEGF)and their relationship with the clinical pathological characteristics of cervical cancer.Methods The expression of COX-2 and VEGF were examined immunohistochemically in 56 cases of cervical cancer and 15 of normal cervix.Results The positive rate of COX-2 and VEGF were significantly different between the cervical carcinoma and normal cervix.The expression of COX-2 in cervical cancer was significantly related to the histological subtypes,the metastasis of lymph node and the differentiation(P0.05);while the expression of VEGF was closely related to clinical stage,the metastasis of lymph node(P0.05).The expression of VEGF was closely associated with COX-2(P0.01).Conclusion The expression of COX-2 and VEGF are related to the oncogenesis and development of cervical cancer and they may play important roles in the invasion and metastasis of cervical cancer.

Key concepts: Medicine, Cervical cancer, Vascular endothelial growth factor, Pathological, Cervix, Stage (stratigraphy), Carcinogenesis, VEGF receptors

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The Clinical Significance of Cyclooxygenase-2(COX-2) and Vascular Endothelial Growth Factor(VEGF) in Cervical Cancer — Research Paper | ScholarLens