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Expression and biological significance of COX-2 and VEGF in cervical cancer

Mengzhe Zhang

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Abstract

Objective To investigate the expression of cyclooxygenase-2(COX-2)and vascular endothelial growth factor(VEGF)and their relationship with the clinicopathological characteristics of cervical cancer.Methods The expression of COX-2 and VEGF were examined i mmunohistochemically in 68 cases of cervical cancer and 14 of normal cervix.Results The positive rate of COX-2 and VEGF were significantly different between the cervical carcinoma and normal cervix.The expression of COX-2 in cervical cancer was significantly related to the histological subtypes,the metastasis of lymph node and the differentiation(P0.05);while the expression of VEGF was related to clinical stages,the metastasis of lymph node(P0.05).The expression of VEGF was closely associated with COX-2(P0.01).Conclusions The expression of COX-2 and VEGF are related to the oncogenesis and development of cervical cancer and they may play important roles in the invasion and metastasis of cervical cancer.

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Objective To investigate the expression of cyclooxygenase-2(COX-2)and vascular endothelial growth factor(VEGF)and their relationship with the clinicopathological characteristics of cervical cancer.Methods The expression of COX-2 and VEGF were examined i mmunohistochemically in 68 cases of cervical cancer and 14 of normal cervix.Results The positive rate of COX-2 and VEGF were significantly different between the cervical carcinoma and normal cervix.The expression of COX-2 in cervical cancer was significantly related to the histological subtypes,the metastasis of lymph node and the differentiation(P0.05);while the expression of VEGF was related to clinical stages,the metastasis of lymph node(P0.05).The expression of VEGF was closely associated with COX-2(P0.01).Conclusions The expression of COX-2 and VEGF are related to the oncogenesis and development of cervical cancer and they may play important roles in the invasion and metastasis of cervical cancer.

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Available abstract

Objective To investigate the expression of cyclooxygenase-2(COX-2)and vascular endothelial growth factor(VEGF)and their relationship with the clinicopathological characteristics of cervical cancer.Methods The expression of COX-2 and VEGF were examined i mmunohistochemically in 68 cases of cervical cancer and 14 of normal cervix.Results The positive rate of COX-2 and VEGF were significantly different between the cervical carcinoma and normal cervix.The expression of COX-2 in cervical cancer was significantly related to the histological subtypes,the metastasis of lymph node and the differentiation(P0.05);while the expression of VEGF was related to clinical stages,the metastasis of lymph node(P0.05).The expression of VEGF was closely associated with COX-2(P0.01).Conclusions The expression of COX-2 and VEGF are related to the oncogenesis and development of cervical cancer and they may play important roles in the invasion and metastasis of cervical cancer.

Key concepts: Cervical cancer, Medicine, VEGF receptors, Carcinogenesis, Vascular endothelial growth factor, Lymph node metastasis, Cervix, Metastasis

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