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2010•Unpublished venueRequires access

Correlation of reactive oxygen species and apoptosis induced by resveratrol in drug-resistant K562/ADM cell

I Hulai

Open publisher page 1 citations

Abstract

Objective:To investigate the apoptosis of K562/ADM cells induced by resveratrol and the influence of intracellular reactive oxygen species(ROS)level.Methods:MTT assay,light and electronic microscopy and cell cycle analysis were used to examine apoptosis in K562/ADM cells.Intracellular ROS level was measured with flow cytometry(FCM).Results:Resveratrol inhibited growth of K562/ADM cells.Morphological changes typical of apoptosis were observed through light and electronic microscopy.Cell cycle analysis indicated increased S phase proportion,as well as apparent S/G2 phase arrest.After application of resveratrol,the level of ROS markedly increased.Conclusions:Resveratrol induces apoptosis in K562/ADM cells might be through stimulating ROS production.

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What this paper is about

Objective:To investigate the apoptosis of K562/ADM cells induced by resveratrol and the influence of intracellular reactive oxygen species(ROS)level.Methods:MTT assay,light and electronic microscopy and cell cycle analysis were used to examine apoptosis in K562/ADM cells.Intracellular ROS level was measured with flow cytometry(FCM).Results:Resveratrol inhibited growth of K562/ADM cells.Morphological changes typical of apoptosis were observed through light and electronic microscopy.Cell cycle analysis indicated increased S phase proportion,as well as apparent S/G2 phase arrest.After application of resveratrol,the level of ROS markedly increased.Conclusions:Resveratrol induces apoptosis in K562/ADM cells might be through stimulating ROS production.

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Available abstract

Objective:To investigate the apoptosis of K562/ADM cells induced by resveratrol and the influence of intracellular reactive oxygen species(ROS)level.Methods:MTT assay,light and electronic microscopy and cell cycle analysis were used to examine apoptosis in K562/ADM cells.Intracellular ROS level was measured with flow cytometry(FCM).Results:Resveratrol inhibited growth of K562/ADM cells.Morphological changes typical of apoptosis were observed through light and electronic microscopy.Cell cycle analysis indicated increased S phase proportion,as well as apparent S/G2 phase arrest.After application of resveratrol,the level of ROS markedly increased.Conclusions:Resveratrol induces apoptosis in K562/ADM cells might be through stimulating ROS production.

Key concepts: Resveratrol, Apoptosis, Reactive oxygen species, Flow cytometry, Intracellular, K562 cells, Chemistry, Cell cycle

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Correlation of reactive oxygen species and apoptosis induced by resveratrol in drug-resistant K562/ADM cell — Research Paper | ScholarLens