Effect and Analysis of Clinical Efficacy of Immunomodulator on Serum Levels of IL-4 and IFN-γ in Asthmatic Children

【Objective】 To investigate the effect and clinical efficacy of immunomodulator on serum Th1 / Th2 cytokines in asthmatic children. 【Methods】 Forty-five children of asthma at acute stage were enrolled and divided into two groups. Twenty-nine cases took bacterial lysates (Broncho-Vaxom, BV) in treatment group / BV group. Sixteen cases were given the same amount of inhaled corticosteroids (ICS) for treatment in control group / ICS group. Blood samples of all patients were drawn before and 12 months after treatment to detect the serum IL-4 and IFN-γ and total plasma IgE levels, and their lung functions were measured as well. All of them were followed up for one year. 【Results】 The frequencies of emergency visiting for asthma attack and respiratory tract infection in treatment group were (1.32 ± 1.03) and (1.32 ± 1.03) respectively, while in control group the frequencies were (2.17 ± 1.52) and (3.78 ± 1.81) respectively. The differences between the two groups had statistical significance (P 0.05). The frequencies of respiratory tract infection were positively correlated with that of asthma relapse in both groups (P 0.01). IgE levels did not decrease obviously in both groups after treatment. Serum level of IL-4 did not change but IFN-γ increased obviously in treatment group. In control group, serum level of IL-4 decreased and IFN-γ increased. The ratios of IFN-γ / IL-4 in both groups increased obviously compared with that before treatment and the differences had statistical significance (P 0.05). The ratios of IFN-γ / IL-4 before and after treatment in both groups had no statistical significances (P 0.05). The lung function index in treatment group was better than that in control group (P 0.05). 【Conclusions】 Broncho-Vaxom not only enhances the specific and non-specific immune defense function of respiratory tract, reduces the risk factors of inducing asthma, corrects the expression migration of Th1/Th2 type cytokines, but also regulates the immune abnormality of asthmatic children.