Influence of bacterial lysates combined with montelukast sodium on serum immunoglobulin, interferon-γ and interleukin-4 in asthma and analysis of the clinical efficacy

Objective To observe the influence of bacterial lysates (broncho-vaxom) combined with montelukast sodium on serum immunoglobulin, interferon (IFN)-γ and interleukin (IL)-4 in asthma and the clinical efficacy. Methods Thirty-one patients with asthma in acute period of onset in children (study group) received broncho-vaxom combined with montelukast sodium for 3 months on the basis of conventional treatment. The changes of serum IgG, IgA, IgM, IFN-γ and IL-4 levels before and after treatment were observed and compared with 31 healthy children (control group), the score changes of day and night symptom were also observed before and after treatment. Results IgG and IgA levels were abnormal significantly in study group before treatment (P < 0.05 ), they were significantly increased after treatment, but IgG was still significantly lower than that in control group (P < 0.05 ). IFN-γ and IL-4 were significantly abnormal in study group before treatment (P < 0.05), IFN-γ was significantly increased after treatment (P<0.05), while IL-4 was significantly decreased (P<0.05); after 3 months of treatment, the score of day and night symptom in study group were (0.4±0.1 ) and (0.7±0.2) scores respectively, which both decreased significantly than those before treatment [(2.6±0.3 ) and (3.4±0.7) scores respectively],the difference were statistically significant(P < 0.05 ). Conclusion Children with asthma have the existence of decreased immune function, application of broncho-vaxom combined with montelukast sodium can effectively control its symptoms and improve immune status. Key words: Immunoglobulins; Interferon type Ⅱ ; Interleukin-4; Bacterial lysates; Montelukast