Correlation of X-ray Features in Mammography and Expression of OPN and ON of Breast Carcinoma

Objective To investigated the expression of OPN and ON in breast carcinoma, and analyze its relationship with X-ray Features in mammography.Materials and Methods Immunohistochemical SP method was used to examine the expression of OPN and ON in 29 cases breast benign disease (including 8 cases intraductal papilloma and 21cases fibroadenoma) and 61 cases invasive breast cancer, relationship of expression of OPN and ON and x ray findings, pathological results were analyzed. Results The positive rates of OPN and ON expression in 61cases breast cancer were higher than those in breast benign diseases (72.13%, 77.05%, respectively,χ~2=6.310,χ~2=13.126,P0.05); The positive rates of OPN and ON expression in calcification group were 87.50% and 91.67% respectively, compared with non-calcification group, there were obviously differential expression (χ~2=4.649,χ~2=4.781,P0.05); There were no significant difference in mass, spicule, lymph npdes metastasis and clinic-pathologic with expression of OPN and ON. Conclusion The expression of OPN and ON are high in breast cancer, the mammographic features can reflect the expression of OPN and ON, so the biological behavior and prognosis of breast cancer can be assessed by mammographic features to some extent.