Expression and Clinicopathlogic Significance of OPN and ON in Breast Carcinoma

Objective To investigate the expressions of osteopontin (OPN) and osteonectin (ON) and their clinicopathologic significance in breast carcinoma. Methods Immunohistochemical method was used to examine the expression of OPN and ON in 61 cases invasive breast carcinoma The relationships of OPN and ON expression with clinicpathologic and mammographic features were analyzed. Results The high positive expression rates of OPN and ON expression in 61cases breast carcinoma were 72.13% and 77.05% respectively, which were significantly higher than that in benign breast tumors (P 0.05). The high positive expression of OPN and ON in cases with microcalcification in mammography was significantly higher than that in the cases without microcalcification (P 0.05). No statistical relationship was found between the expressions of OPN and ON in breast carcinoma with the ages of patients, pathologic types, differentiation, lymph node metastasis as well as spicule signs in mammography. Conclusion The expression of OPN and ON is higher in breast carcinoma, which is significantly related with microcalcification, but not with other clinic-pathologic features.