Expression of OPN in recurrent and metastatic breast cancer

Objective:To explore the expression of OPN in recurrence and metastasis of breast cancer.To investigate the relationship between OPN and ER,PR,C-erbB-2,p53 and the clinical pathological factors in breast cancer.Methods: Forty cases with recurrence or metastasis in 5 years(Group A),30 cases without recurrence or metastasis in 5 years(Group B),and 10 cases with breast fibroma(Group C)and 15 cases with normal breast tissue(Group D),which were surgically resected in the Department of Breast Surgery,XiangYa Hospital,from 1996 to 2001,were included in this study.The expressions of OPN were studied in four groups by immunohistochemical staining technique.All statistics analysis was used by SPSS 11.5 for window.Results:The expression positive rate of OPN was 72.86%(51/70) in breast cancer,which was different from Group C and Group D.OPN positive expression was not correlated with that of ER,PR,C-erbB-2,p53,and clinical pathological factors such as age,pathological,neoadjuvant chemotherapy(P0.05).However OPN positive expression was correlated with p53.There was statistically significant difference on expression of OPN between Group A and B.Conclusion: OPN may be correlated with the development of breast carcinoma and associated with the prognosis of breast cancer.