Expression of Osteopontin in Invasive Breast Cancer and its Clinical Significance

Objective To investigate the expression of osteopontin(OPN) and its clinical significance in breast cancer and the adjacent normal breast tissue.Methods A total of 87 invasive breast cancer samples were collected from patients who were treated during Jan.2006 to Dec.2007 in the second subsidiary hospital of Nantong university.Expression of OPN、c-erbB-2、ER、PR by immunohistochemistry and analyzed with patients clinical and pathological features.Results The positive expression rate of OPN was 61.7% in 47 invasive ductal carcinoma,and 33.3% inⅠgrade,58.8% in Ⅱgrade,83.3% in Ⅲ grade.OPN expression positive rates were 38.9% in invasive lobular carcinoma.OPN expression in lymph node positive was 65.9 %,lymph node negative was 39.1%.There were 70% OPN expression Among 40 c-erbB-2 expression.These showed that the expression of OPN was significantly correlated with histological grade、axillary lymph node metastasis and c-erbB-2 status(P0.05),but not with age、tumor size、histological type and ER、PR status(P0.05).Conclusion In breast cancer,OPN is highly expressed in axillary lymph node metastasis and c-erbB-2 over-expression subtypes,which indicates that OPN maybe a useful indicator for prognosis of breast carcinoma.