Clinical observation of three dimensional conformal radiotherapy in lung cancer with brain metastasis

Objective:Through the observation of result of conformal radiotherapy, to explore the clinical significance of three dimensional conformal radiotherapy to treat the brain metastasis of non-small cell lung cancer. Methods: Amomg 41 patients of lung cancer with brain metastasis 18 were combined with extra cranial metastasis, and the other 23 cases without extra cranial metastasis. All patients were treated by whole brain irradiation therapy(WBRT) 2-3Gy for 5 times/week, and the total dosage was 30Gy-40Gy, then treated by conformal radiotherapy. The 90% equi-dosage line include the target area: Fraction dosage was 4-6Gy/time and 5 times week according the size of target area , and the accumulative radiotherapy dosage was 12Gy-24Gy. Results: The effective rate was 90.2%(37/41), the media survival time was 18 months,the half one year survival rate was 79.9%, 1-year survival rate was 66.7%. Conclusion: Three dimensional conformal radiotherapy can increase the dosage of metastasis focus,and have significant effect of improving local control rate of three dimension conformal radiotherapy to treat brain metastasis.