Efficacy of Three-Dimensional Conformal Radiotherapy Combined with Whole Brain Irradiation for Brain Metastasis

Objective: To observe the early efficacy of three-dimensional conformal radiotherapy combined with whole brain irradiation for patients with brain metastasis. Methods: 33 patients were treated by whole brain irradiation first,the dosage was 36Gy～40Gy/(18f～20f).And then a dosage of 20Gy～25Gy was added to the focus of metastasis by three-dimensional conformal radiotherapy,fraction dosage was 2Gy～5Gy/fraction and 5 times/week or 3 times/week. Results: Within 1 month after radiotherapy,the CR of imaging was 45.5%,PR was 36.4%,NC was 15.1%,and PD was 3%.The significant remission rate of symptoms and signs in 32 cases was 40.6%,partial remission rate was 59.4%.The median survival time was 9.3 months. Conclusion: The three-dimensional conformal radiotherapy combined with whole brain irradiation for brain metastasis is effective in controlling the focus of brain,improving life quality and prolonging surviva1 time as well.