Observation of Curative Effect of Whole Brain Irradiation Combined with Three-dimensional Conformal Radiotherapy on Non-small Cell Lung Cancer with Brain Metastasis

Objective:To discuss and analyze the curative effect of whole brain irradiation combined with three-dimensional conformal radiotherapy on non-small cell lung cancer with brain metastasis.Methods:Retrospectively analyzed the 43 patients suffered from non-small cell lung cancer with brain metastases treated in our hospital from Mar 2006 to Oct 2010.The patients were randomly divided into control group and observation group.The control group was treated only with whole brain radiotherapy(DT 30 Gy/10F),while the observation group was treated with three-dimensional conformal radiotherapy in addition to whole brain radiotherapy,and the dose for the observation group was increased to 45 Gy.Results:All patients received a complete radiotherapy,and no significant adverse reactions and complications were found,the results showed that the observation group was better than the control group.The effective control rate of the observation group was up to 91.7%,and the mean survival time of this group was 12 months,the 1-year survival rates of the two groups were 33.3%(8/24) and 26.3%(5/19) respectively,and the 2-year survival rates were 8.3%(2/24) and 5.3%(1/19) respectively,treatment failure was mainly due to tumor recurrence or systemic multiple metastases.Conclusion:The whole brain irradiation combined with three-dimensional conformal radiotherapy(3D CRT) can effectively improve patients' local control rate,improve their quality of life and prolong the survival period to a certain extent.