Three Dimension Radiotherapy of Lung Cancer with Brain Metastasis

Objective Through the observation of result of conformal radiotherapy,to explore the clinical significance of three dimension conformal radiotherapy to treat the brain metastasis of lung cancer.Methods There have 35 case patients of lung cancer with brain metastasis,and 12 of them combined with extracranial metastasis, and the other 23 cases don’t exist extracranial metastasis.All patients were treated by whole brain irradiation, 1.8 ~2 Gy/time for 5 times/week,and the total dosage was 30~40Gy.And then were treated by conformal radiotherapy,the 90% equi-dosage line include the target area; fraction dosage was 2~6Gy/time and 5 times/week according to the size of target area,and the accumulative radiotherapy dosage was 20~40Gy.Results the effective rate(CR+PR)was 85%(30/35).the effect of patients with brain tumor size less than 3cm before treatment was superior to that of excess of 3cm.Survival time:the median survival time was 10.3 month. Conclusion The three dimension conformal radiotherapy can increase the dosage of metastasis focus,and have significant effect of improving local control rate of focus,and can reduce the death rate died of brain focus recurrence.At the mean time when we use the three dimension conformal radiotherapy to treat brain metastasis,it is also important to treat extracranial metastasis and primary tumor.