2013•Zhongguo shiyan fangjixue zazhiRequires access
Protective Effect of Cuscuta chinensis on the Movement Renal Ischemia-reperfusion in Rats
Guo Ai-mi
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Abstract
Objective: To study Cuscuta chinensis.protective effect and mechanism of movement renal ischemia-reperfusion injury in rats.Method: Divided the 75 7-week-old male Wistar rats into 4 groups randomly: control group(group C,12),general training group(group M,12),overtraining group(group OM,24),C.chinensis + overtraining group(group COM,24),56 days of exhaustive swimming training.The COM group with professional gavages for gastric lavage(ig) once a day,the dose was 6.96 g·kg-1and ig volume was 5 mL·kg-1;other groups were for ig normal saline.Detect biochemical parameters of serum urea nitrogen and serum creatinine after 24 hours when the last training ends.Result: In the 8 week of overtraining rats resulted in movement of ‘renal ischemia reperfusion'and disordered free radicals metabolism.The ultrastructure of kidney was severely damaged,the histopathological changes obviously,and renal function was seriously damaged.Serum creatinine and blood urea nitrogen of OM group and COM group were higher than in group C(P 0.01);COM group was lower than the OM group(P 0.05).SOD activity of OM group and COM group were lower than in group C(P 0.01);COM group was higher than the OM group(P 0.05).The content of MDA in OM group and COM group was higher than in group C(P 0.01);COM group was lower than the OM group(P 0.05).Conclusion: C.chinensis can improve disordered free radicals metabolism in overtraining rats which is caused by renal ischemia reperfusion.Kidney ultramicrostructure is normal.Moreover,it has a protective effect on exercise-induced ischemia-reperfusion kidney.