2013•Tianran chanwu yanjiu yu kaifaRequires access
Protective Effect of Morindae Officinalis Combined with Vitamin C on Exercise-induced Renal Ischemia-reperfusion Injury of Rats
Guo Ai-mi
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Abstract
In this study,the protective effect and mechanism of Morindae Officinalis combined with vitamin C on exercised-induced renal ischemia-reperfusion injury of rats was investigated. The rats was gavaged with 1 g / kg of Morindae Officinalis and intraperitoneal injected with 100 mg / kg of vitamin C for 56 days. Exhaustive swim training of the rats was carried out and the blood urea nitrogen and other biochemical indexes were measured. The results showed that 8 weeks of overtraining led to exercised-induced renal ischemia-reperfusion in rats. In addition,the kidney histopathology of rats was significantly changed and renal function was severely damaged. Compared with the control group,the blood urea nitrogen and serum creatinine of each group increased significantly: compared with OM group,MOM group,VCOM group,MVCOM group deceased significantly( P 0. 05,P 0. 05,P 0. 01); compared with VCOM group,MOM group,MVCOM group decreased significantly( P 0. 05,P 0. 01). Compared with the control group,the activity of SOD in each group was significantly decreased: compared with OM group,MOM group,VCOM group,MVCOM group increased significantly( P 0. 05,P 0. 05,P 0. 01); compared with VCOM group,MOM group,MVCOM group increased significantly( P 0. 05,P 0. 01). The content of MDA in each group was significantly higher than that of the control group: compared with OM group,MOM group,VCOM group and MVCOM group decreased significantly( P 0. 05,P 0. 05,P 0. 01);compared with VCOM group,MOM group and MVCOM group significantly decreased( P 0. 05,P 0. 01). The experimental results showed that the combination of Morindae Officinalis and vitamin C had a protective effect on exercise-induced renal ischemia-reperfusion injury of rats.