Expression of P16 and VEGF in Gastric Carcinoma and Its Clinical Significance

Objective To research the behaviour of P16-cancer suppressor gene and Vascular endothelial growth factor(VEGF) in Gastric cancer tissue and the relationship between it and Clinical pathology parameters.Methods The expression of P16 and VEGF in 78 specimens of gastric carcinoma and 15 specimens of benign lesion of stomach were detected by S-P immunohistochemical method and the morphometry quantitative method.Results The positive expression rate of VEGF in gastric carcinoma was taller than in benign lesion of stomach and VEGF main express in tumour cytoplasm or membrane,and it related with lymph node metastasis of gastric cancer and clinical stage(P0.01).The positive expression rate of P16 in gastric carcinoma was lower than in benign lesion of stomach and P16 main express in tumour nuclear,and it related with lymph node metastasis of gastric cancer and clinical stage(P0.05).P16 high expression notability related with VEGF low expression(P0.01).Conclusion VEGF promote tumor angiogenesis.Up regulation of VEGF expression or down regulation of P16 expression is very important role to the occurrence,development and transfer of gastric carcinoma,and it provide a very important indicator for biological behavior and metastasis in patients of tumour.