Clinical application of serologic screening and confirmation tests for Treponema pallidum infection

Objective To study the importance and necessity of the screening and confirmation of Ttreponema pallidum infection by two serologic tests simultaneously. MethodsSerum samples were determined by rapid plasma reagin test(RPR) and Treponema pallidum particle assay(TPPA). ResultsSerum samples from 6 528 patients who consulted dermatology department or received blood transfusion were tested simultaneously by RPR and TPPA,and the positive samples were retested for titration.The positive rate was 1.29% by RPR and 1.90% by TPPA,while the positive rate was 1.15% in both tests. ConclusionsTo early diagnose the infection and block the transmission pathway,the application of two serologic tests simultaneously to detect anti Treponema pallidum antibody is necessary for the screening of blood donor and diagnosis of suspected infection.