2007•ZhongchengyaoRequires access

Inhibitory effect of the serum containing Compound Liuyuexue on HBsAg and HBeAg in the HepG2.2.15 cells

Renbin Huang

Abstract

AIM:To study the inhibitory effect of Compound Liuyuexue(Tarphochlamys affinis(Giff) Bremekhu,Herba Hedyotis,Raidx Gardeniae,etc.)(CLYX) on HBV in vitro.METHODS:The serum containing CLYX was added to cultured HepG2.2.15 cells,and HepG2.2.15 cells were cultured in medium containing the serum with CLYX for 72 h and 144 h.The culture media were collected for determining the levels of HBsAg and HBeAg by ELISA.RESULTS:The serum containing CLYX could markedly inhibit HBsAg and HBeAg expressions in the HepG2.2.15 cells(P(0.05),P(0.01)).The anti-HBV effect of CLYX was dose-dependent.CONCLUSION:CLYX can significantly inhibit HBV in vitro.

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Key concepts: HBeAg, HBsAg, In vitro, Inhibitory postsynaptic potential, Chemistry, Pharmacology, Virology, Molecular biology